Publications

(Published at University of Illinois at Urbana-Champaign)

Lizarazo S, Yook Y, and Tsai NP (2022) Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2. J Cell Physiol 237:2929-2942 [Link to paper]

Lodes DE, Zhu J, and Tsai NP (2022) E3 Ubiquitin Ligase Nedd4-2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress. J Neurochem 160:613-624 [Link to paper]

Liu X, Kumar V, Tsai NP and Auerbach BD (2022) Hyperexcitability and Homeostasis in Fragile X Syndrome. Front Mol Neurosci (Review) (in press)

Lee KY, Zhu J, Cutia CA, Christian-Hinman CA, Rhodes JS and Tsai NP (2021) Infantile spasm-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling. EMBO Rep 22:e52645 Link to paper

Liu DC, Lee KY, Lizarazo S, Cook JK and Tsai NP (2021) ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model. Neurobiol Dis 158: 105450 Link to paper

Eagleman DE, Zhu J, Liu DC, Seimetz J, Kalsotra A and Tsai NP (2020) Unbiased Proteomic Screening Identifies a Novel Role for the E3 Ubiquitin Ligase Nedd4-2 in Translational Suppression during ER Stress. J Neurochem 157:1809-1820 Link to paper

Liu DC, Soriano S, Yook Y, Lizarazo S, Eagleman DE and Tsai NP (2020) Chronic activation of Gp1 mGluRs leads to distinct refinement of neural network activity through non-canonical p53 and Akt signaling. eNeuro 0438-19.2020 Link to paper

Zhu J and Tsai NP (2020) Ubiquitination and E3 Ubiquitin Ligases in Rare Neurological Disorders with Comorbid Epilepsy. Neuroscience. (Review) 428:90-99 Link to paper

Liu DC, Eagleman DE and Tsai NP (2019) Novel Roles of ER Stress in Repressing Neural Activity and Seizures through Mdm2- and p53-dependent Protein Translation. PLOS Genet. 15(9):e1008364 Link to paper

Zhu J, Lee KY, Jong TY and Tsai NP (2019) C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms. J Neurochem 151: 289-300 Link to paper

Kim EC, Zhang J, Pang W, Wang S, Lee KY, Cavaretta JP, Walters J, Procko E, Tsai NP, and Chung HJ (2018) Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy. Neurobiology of Disease 118:76-93

Jewett KA, Lee KY, Eagleman DE, Soriano S and Tsai NP (2018) Dysregulation and restoration of homeostatic network plasticity in fragile X syndrome mice. Neuropharmacology 138:182-192 Full text here

Lee KY, Jewett KA, Chung HJ and Tsai NP (2018) Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2. Hum Mol Genet. 27:2805–2816 Full text here

Baculis BC, Weiss AC, Pang W, Jeong HG, Lee JH, Liu DC, Tsai NP and Chung HJ. (2017) Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels. Sci Rep. 7:12313

Liu DC, Seimetz J, Lee KY, Kalsotra A, Chung HJ, Lu H and Tsai NP (2017) Mdm2 mediates FMRP- and Gp1 mGluR-dependent Protein Translation and Neural Network Activity. Hum Mol Genet. 26:3895–3908 Full text here

Zhu J, Lee KY, Jewett KA, Man HY, Chung HJ and Tsai NP (2017) Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. PLOS Genet. 13:e1006634 Full text here # Highlighted by Epilepsy Currents

Tsai NP* and Huber KM* (2016) Protocadherins and the Social Brain. Biol Psychiatry. (*co-corresponding authors) (Commentary) 81:173-174

Tsai NP*, Wilkerson, JR, Guo, W, and Huber KM* (2016) FMRP-Dependent Mdm2 Dephosphorylation is required for MEF2-Induced Synapse Elimination. Hum Mol Genet. (*co-corresponding authors) 26:293-304

Jewett KA, Christian CA, Bacos JT, Lee KY, Zhu J, and Tsai NP (2016) Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling. Mol Brain 9:32

Jewett KA, Zhu J, and Tsai NP (2015) The tumor suppressor p53 guides Glua1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity. J Neurochem 135:226-233

Tsai NP* (2014). Ubiquitin Proteasome System-Mediated Degradation of Synaptic Proteins: An Update from the Postsynaptic Side. Biochimica et Biophysica Acta 1843:2838-2842

(Published at University of Texas Southwestern Medical Center)

Wilkerson JR*, Tsai NP*, Maksimova MA, Wu H, Cabalo NP, Loerwald KW, Dictenberg JB, Gibson JR and Huber KM (2014). A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination. Cell Rep 7:1589-1600 (*equal contribution)

Jakkamsetti V, Tsai NP, Gross C, Molinaro G, Collins KA, Nicoletti F, Wang KH, Osten P, Bassell GJ, Gibson JR and Huber KM (2013) Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for mGluR-dependent long-term synaptic depression. Neuron 80:72-79

Tsai NP*, Wilkerson, JR*, Guo, W, Maksimova, MA, DeMartino, GN, Cowan CW and Huber KM (2012) Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell 151: 1581-1594 (*equal contribution)

Ronesi JA, Collins KA, Hays SA, Tsai NP, Guo W, Birnbaum SG, Hu JH, Worley PF, Gibson JR, Huber KM (2012) Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat Neurosci 15: 431-440, S431.

(Published at University of Minnesota)

Tsai NP, Lin YL, Tsui YC, Wei LN (2010) Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA. J Cell Biol 188: 325-333. (Highlights by Short B. (2010). EGF takes dual control of mRNA. J. Cell Biol 188, 300)

Tsai NP, Tsui YC, Pintar JE, Loh HH, Wei LN (2010) Kappa opioid receptor contributes to EGF-stimulated neurite extension in development. Proc Natl Acad Sci U S A 107: 3216-3221.

Tsai NP, Wei LN (2010) RhoA/ROCK1 signaling regulates stress granule formation and apoptosis. Cell Signal 22: 668-675.

Tsai NP*, Huq M*, Gupta P, Yamamoto K, Kagechika H, Wei LN (2009) Activation of testicular orphan receptor 4 by fatty acids. Biochim Biophys Acta 1789: 734-740. (*equal contribution)

Tsai NP, Lin YL, Wei LN (2009) MicroRNA mir-346 targets the 5′-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression. Biochem J 424: 411-418.

Tsai NP, Tsui YC, Wei LN (2009) Dynein motor contributes to stress granule dynamics in primary neurons. Neuroscience 159: 647-656.

Gupta P, Ho PC, Huq MM, Ha SG, Park SW, Khan AA, Tsai NP, Wei LN (2008) Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression. Proc Natl Acad Sci U S A 105: 11424-11429.

Tsai NP, Ho PC, Wei LN (2008) Regulation of stress granule dynamics by Grb7 and FAK signalling pathway. EMBO J 27: 715-726. Gupta P, Ho PC, Huq MD, Khan AA, Tsai NP, Wei LN (2008) PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation. PLoS One 3: e2658.

Bi J, Tsai NP, Lu HY, Loh HH, Wei LN (2007) Copb1-facilitated axonal transport and translation of kappa opioid-receptor mRNA. Proc Natl Acad Sci U S A 104: 13810-13815. Huq MD,

Tsai NP, Khan SA, Wei LN (2007) Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function. Mol Cell Proteomics 6: 677-688.

Huq MD, Tsai NP, Lin YP, Higgins L, Wei LN (2007) Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation. Nat Chem Biol 3: 161-165.

Tsai NP, Bi J, Wei LN (2007) The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. EMBO J 26: 1522-1531.

Bi J, Tsai NP, Lin YP, Loh HH, Wei LN (2006) Axonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root ganglia. Proc Natl Acad Sci U S A 103: 19919-19924.

Huq MD, Gupta P, Tsai NP, Wei LN (2006) Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation. Mol Cell Proteomics 5: 2072-2082.

Huq MD, Tsai NP, Gupta P, Wei LN (2006) Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites. EMBO J 25: 3203-3213.

Huq MD, Gupta P, Tsai NP, White R, Parker MG, Wei LN (2006) Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation. EMBO J 25: 5094-5104.

Tsai NP, Bi J, Loh HH, Wei LN (2006) Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA. J Neurosci 26: 9743-9749.

Tsai NP, Wu YC, Chen JW, Wu CF, Tzeng CM, Syu WJ (2006) Multiple functions of l0036 in the regulation of the pathogenicity island of enterohaemorrhagic Escherichia coli O157:H7. Biochem J 393: 591-599.

Gupta P, Huq MD, Khan SA, Tsai NP, Wei LN (2005) Regulation of co-repressive activity of and HDAC recruitment to RIP140 by site-specific phosphorylation. Mol Cell Proteomics 4: 1776-1784.