Kumar V, Lee KY, Acharya A, Babik MS, Christian-Hinman CA, Rhodes JS and Tsai NP (2024) mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS. EMBO Mol Med 16:506-522 [Link to paper]

Yook Y, Lee KY, Kim E, Lizarazo S, Yu X, and Tsai NP (2024) Hyperfunction of PSD-95 Promotes Seizure Response in Early-Stage Aβ Pathology. EMBO Rep 25:1233-1255 [Link to paper]

Lee KY, Wang H, Yook Y, Rhodes JS, Christian-Hinman CA, and Tsai NP (2023) Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning.  Molecular Psychiatry 28:3782–3794 [Link to paper]

Lizarazo S, Yook Y, and Tsai NP (2022) Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2. J Cell Physiol 237:2929-2942 [Link to paper]

Lodes DE, Zhu J, and Tsai NP (2022) E3 Ubiquitin Ligase Nedd4-2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress. J Neurochem 160:613-624 [Link to paper]

Liu X, Kumar V, Tsai NP and Auerbach BD (2022) Hyperexcitability and Homeostasis in Fragile X Syndrome. Front Mol Neurosci 14:805929 (Review)

Lee KY, Zhu J, Cutia CA, Christian-Hinman CA, Rhodes JS and Tsai NP (2021) Infantile spasm-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling. EMBO Rep 22:e52645 Link to paper

Liu DC, Lee KY, Lizarazo S, Cook JK and Tsai NP (2021) ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model. Neurobiol Dis 158: 105450 Link to paper

Eagleman DE, Zhu J, Liu DC, Seimetz J, Kalsotra A and Tsai NP (2020) Unbiased Proteomic Screening Identifies a Novel Role for the E3 Ubiquitin Ligase Nedd4-2 in Translational Suppression during ER Stress. J Neurochem 157:1809-1820 Link to paper

Liu DC, Soriano S, Yook Y, Lizarazo S, Eagleman DE and Tsai NP (2020) Chronic activation of Gp1 mGluRs leads to distinct refinement of neural network activity through non-canonical p53 and Akt signaling. eNeuro 0438-19.2020 Link to paper

Zhu J and Tsai NP (2020) Ubiquitination and E3 Ubiquitin Ligases in Rare Neurological Disorders with Comorbid Epilepsy. Neuroscience. (Review) 428:90-99 Link to paper

Liu DC, Eagleman DE and Tsai NP (2019) Novel Roles of ER Stress in Repressing Neural Activity and Seizures through Mdm2- and p53-dependent Protein Translation. PLOS Genet. 15(9):e1008364 Link to paper

Zhu J, Lee KY, Jong TY and Tsai NP (2019) C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms. J Neurochem 151: 289-300 Link to paper

Kim EC, Zhang J, Pang W, Wang S, Lee KY, Cavaretta JP, Walters J, Procko E, Tsai NP, and Chung HJ (2018) Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy. Neurobiology of Disease 118:76-93

Jewett KA, Lee KY, Eagleman DE, Soriano S and Tsai NP (2018) Dysregulation and restoration of homeostatic network plasticity in fragile X syndrome mice. Neuropharmacology 138:182-192 Full text here

Lee KY, Jewett KA, Chung HJ and Tsai NP (2018) Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2. Hum Mol Genet. 27:2805–2816 Full text here

Baculis BC, Weiss AC, Pang W, Jeong HG, Lee JH, Liu DC, Tsai NP and Chung HJ. (2017) Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels. Sci Rep. 7:12313

Liu DC, Seimetz J, Lee KY, Kalsotra A, Chung HJ, Lu H and Tsai NP (2017) Mdm2 mediates FMRP- and Gp1 mGluR-dependent Protein Translation and Neural Network Activity. Hum Mol Genet. 26:3895–3908 Full text here

Zhu J, Lee KY, Jewett KA, Man HY, Chung HJ and Tsai NP (2017) Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. PLOS Genet. 13:e1006634 Full text here # Highlighted by Epilepsy Currents

Tsai NP* and Huber KM* (2016) Protocadherins and the Social Brain. Biol Psychiatry. (*co-corresponding authors) (Commentary) 81:173-174

Tsai NP*, Wilkerson, JR, Guo, W, and Huber KM* (2016) FMRP-Dependent Mdm2 Dephosphorylation is required for MEF2-Induced Synapse Elimination. Hum Mol Genet. (*co-corresponding authors) 26:293-304

Jewett KA, Christian CA, Bacos JT, Lee KY, Zhu J, and Tsai NP (2016) Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling. Mol Brain 9:32

Jewett KA, Zhu J, and Tsai NP (2015) The tumor suppressor p53 guides Glua1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity. J Neurochem 135:226-233

Tsai NP* (2014). Ubiquitin Proteasome System-Mediated Degradation of Synaptic Proteins: An Update from the Postsynaptic Side. Biochimica et Biophysica Acta 1843:2838-2842